Microbes and biomaterials are reshaping the prospects for cancer immunotherapy

The day's studies link the gut-brain axis to behavior and expose skewed online perceptions.

Jamie Sullivan

Key Highlights

  • A frog-derived bacterium eradicated mouse tumors after a single dose and conferred lasting protection.
  • 83% of autistic children and adolescents experience life-disruptive sleep disorders, underscoring unmet needs.
  • Researchers analyzed 1,338 mass shootings referenced during the 117th US Congress to chart partisan framing.

Today’s r/science lineup spotlighted three intertwined fronts: microbes and materials reshaping cancer care, the gut-brain-behavior nexus in mental health, and evidence that challenges how society perceives itself. The conversations were punchy, data-driven, and eager to separate signal from noise.

Microbes and materials are reimagining cancer therapy

A standout was the report on a frog gut bacterium eliminating cancer tumors in mice, which described Ewingella americana’s single-dose eradication and lasting protection. In parallel, early clinical work on a personalized, biomaterial-based cancer vaccine demonstrated feasibility, safety, and immune activation, while case reports added a provocative note with cannabis oil associated with tumor regression in advanced liver cancer.

"Japan is killing it on scientific discoveries lately..." - u/TheHumanoidTyphoon69 (5439 points)

Across these threads, the immune system is the common denominator—whether bacteria prime it, biomaterials orchestrate it, or cannabinoids potentially modulate it. The evidence tiers differ dramatically, though: mouse results and case reports invite cautious curiosity, while the vaccine’s first-in-human signal points toward combinations with checkpoint inhibitors to translate immune activation into durable clinical benefit.

The gut-brain-behavior map comes into focus

Fresh findings suggested the biological footprint of adolescent social anxiety may partly reside in the gut, echoing a decade-long shift toward microbiome-informed psychiatry. Complementing that, a systematic review highlighted that 83% of autistic children and adolescents face life-disruptive sleep disorders, and behavioral science chimed in with an analysis indicating that cheaters’ thought processes resemble those of criminals, from calculated risk management to guilt-ameliorating justifications.

"With all this gut bacteria research that has come out in the decade or so, I’m starting to think we are just puppets for them." - u/Cararacs (574 points)

Taken together, these studies argue for multidimensional care—addressing sleep to potentially ease autistic symptom severity, probing gut-brain pathways in adolescent anxiety, and recognizing cognitive patterns that drive harmful behavior. The community’s responses also flagged likely comorbidities and the need for robust, longitudinal designs to untangle causality from correlation.

Perception, narrative, and the discipline of evidence

One social-science thread argued that a loud minority makes the internet seem more toxic than it is, skewing how Americans view one another online. In parallel, researchers mapped how members of the 117th US Congress framed mass shootings on social media, revealing consistent partisan patterns that shape public discourse around guns, victims, and policy.

"Most people don't comment at all. Vocal minorities control Internet culture." - u/VideoPup (558 points)

The day also underscored the value of publishing negative results, as a randomized trial found that valacyclovir worsened cognitive decline in early Alzheimer’s compared to placebo—a necessary correction in the scientific record. And curiosity stayed alive with a striking natural history update: the discovery of bees nesting in fossil bones in a Caribbean cave, a reminder that evidence can upend assumptions not just about society, but about nature itself.

Every subreddit has human stories worth sharing. - Jamie Sullivan

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Sources

TitleUser
Frog gut bacterium eliminates cancer tumors in mice with a single dose: Single shot of E. americana intravenously to mice with colorectal cancer completely eliminated tumors in every treated animal, with ongoing protection. When mice were later re-exposed to cancer cells, none developed new tumors.
12/17/2025
u/mvea
29,989 pts
83% of autistic children and adolescents suffer from life-disruptive sleep disorders including difficulty falling asleep, night walking, night terrors, movement during sleep, and reduced sleep duration, which exacerbate autistic symptom severity, in a peer-reviewed systematic review
12/17/2025
u/sometimeshiny
6,606 pts
A loud minority makes the internet seem more toxic than it is. A small group of active users generates most hostility, while the majority remain civil. This imbalance leads many Americans to assume the worst about one another. Correcting that misperception can improve how people feel about society.
12/18/2025
u/Sciantifa
5,162 pts
1,338 mass shootings took place during 117th US Congress. Democrat members were more likely to tweet about guns after mass shootings than Republicans. Democrats tended to post about community, families, victims, and legislature, while Republicans post about 2nd Amendment, law enforcement, and crime.
12/17/2025
u/mvea
4,654 pts
The thought processes of cheaters closely resemble those of criminals, study suggests. Researchers found that individuals often turn to infidelity to cope with life stressors, utilize calculated strategies to avoid detection, and employ specific psychological justifications to alleviate guilt.
12/17/2025
u/mvea
2,971 pts
Scientists find the biological footprint of social anxiety may reside partially in the gut Findings suggest that specific alterations in the gut-brain axis could contribute to the pathology of social anxiety during adolescence.
12/17/2025
u/No-Explanation-46
1,767 pts
People diagnosed with early Alzheimers given the herpes medication valacyclovir actually experienced worse cognitive decline than those given a placebo Valacyclovir Treatment of Early Symptomatic Alzheimer Disease: The VALAD Randomized Clinical Trial
12/17/2025
u/Hrmbee
1,015 pts
In a Caribbean cave, researchers discovered hundreds of fossils with bee nests within them. It's the first time bees have been recorded using bones to nest and lay eggs, according to a new study.
12/17/2025
u/cnn
911 pts
First-in-human clinical trial of personalized, biomaterial-based cancer vaccine demonstrates feasibility, safety, and immune activation
12/17/2025
u/ltogirl1
660 pts
Case Reports: Cannabis Oil Associated With Tumor Regression in Patients With Advanced Liver Cancer
12/17/2025
u/OhMyOhWhyOh
462 pts