A first enteral ventilation trial signals a push for redundancy

The analysis links policy risks to child mortality and shows how resilient systems evolve.

Jamie Sullivan

Key Highlights

  • Modeling warns that U.S. global health cuts could drive nearly 9 million pediatric TB cases and up to 1.5 million child deaths.
  • Researchers conduct a first-in-human safety trial of enteral ventilation as a potential alternative airway.
  • Engineers propose the Amigo mesh protocol to preserve local connectivity when centralized networks fail, without providing internet access.

Today’s r/science conversations toggle between bold rethinks of the human body, the societal forces that steer public health, and the ways both nature and networks adapt under pressure. The throughline: when an established pathway is blocked or brittle, systems invent new ones—biological, political, and technological alike.

Rethinking bodies: from alternative airways to additive metabolism

The day’s most upvoted thread turned a punchline into a pipeline for innovation, as researchers behind an Ig Nobel headline advanced a sober milestone with a first-in-human safety trial of enteral ventilation. That same appetite for overturning assumptions showed up in metabolism research, with evidence that moving more truly adds to total daily energy rather than being offset elsewhere, and in cell biology, where a suggestion that graying hair may be a cancer-defense tradeoff reframed what aging signals might mean for risk.

"The Ig Nobel prize isn't the Razzies. It's not an award for useless science, it's an award for good science that at first sounds funny but which shows something interesting. Winning one and then doing something useful isn't surprising, it's the whole point!" - u/Nixeris (1662 points)

Clinical advice threads likewise shifted from slogans to specifics: a long-term cohort study challenged the idea that weight loss is essential to reverse prediabetes, emphasizing glucose control and fat distribution over the scale. And life-course effects surfaced in men’s health with a large dataset linking childhood obesity to shorter adult penile length, underscoring how early endocrine environments can cast long shadows.

Health at scale: when funding, behavior, and politics steer outcomes

Zooming out, the community weighed the stark arithmetic of policy, as modelers warned that U.S. global health cuts could drive millions of pediatric TB cases and 1.5 million child deaths. Another line of inquiry examined how mindsets map onto politics, with research indicating that national nostalgia predicts greater prejudice and higher support for Trump, while future-focused “prostalgia” correlates with lower prejudice and support—an uncomfortable reminder that sentiment can silently set priorities.

"It’s so dispiriting that this is a very solvable problem... Funding cuts at this stage are inexcusable." - u/HicJacetMelilla (734 points)

Public discourse itself came under the microscope with work on adversarial tactics online, highlighting how “faux fandom” can poison the well; researchers presented an ML approach to detect fanchuan-style trolling that impersonates supporters to smear targets. From budget lines to belief systems to bad actors, the takeaway is consistent: the information environment shapes health outcomes long before a patient reaches a clinic.

Networks and nature: resilient systems evolve

Resilience was the motif across scales. In the oceans, evolutionary biologists traced how cetaceans took a radical turn when they lost a fat-burning gene and shifted to insulating blubber, a genomic trade that unlocked survival in cooling seas. On the streets, engineers showcased a protest-optimized mesh protocol, proposing Amigo as a way to keep local connectivity when centralized networks falter.

"Important to remember that this creates a local network, not a connection to the internet." - u/Definitely_Not_Bots (243 points)

Across these threads, the pattern repeats: when one channel—be it airway, funding stream, or radio backhaul—closes, systems adapt by building alternatives. r/science’s debate today kept returning to that pragmatic lesson: durability favors designs that don’t rely on a single point of failure, whether in physiology, public health, or the networks that carry both ideas and oxygen.

Every subreddit has human stories worth sharing. - Jamie Sullivan

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Sources

TitleUser
Scientists that won the 2024 IgNobel Prize for "discovering that many mammals are capable of breathing through their anus" have completed a successful first-in-human trial testing the safety and tolerability of enteral ventilation, a technique that gets oxygen-rich fluid pumped into the anus.
10/21/2025
u/mvea
10,457 pts
U.S. funding cuts could result in nearly 9 million child tuberculosis cases, 1.5 million child deaths
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u/HarvardChanSPH
9,733 pts
National nostalgia (a sentimental longing for how the country used to be) predicts greater support for Donald Trump and more prejudiced views. In contrast, national prostalgia (a sentimental longing for a better future) tends to reduce prejudice and predicts lower support for Trump.
10/21/2025
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Being active adds to the total energy you use every day without causing the body to conserve energy in other ways like constraint or compensation
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u/nohup_me
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u/IEEESpectrum
1,650 pts
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u/asbruckman
681 pts
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u/nohup_me
537 pts
Scientists discovered that whales lost a crucial fat-burning gene (ADRB3) 32-34 million years ago. This genetic loss meant whales couldn't burn fat for warmth. Instead, they evolved thick blubber for insulation a key adaptation that enabled modern whale diversity and survival in cooling oceans.
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u/orcinus__orca
235 pts
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214 pts