A forensic review ties restraint deaths to carbon dioxide buildup

The findings arrive alongside breakthroughs in precision therapies and sex-specific cardiac diagnostics.

Alex Prescott

Key Highlights

  • A 32-year review of 52 restraint-related deaths identifies carbon dioxide retention, not oxygen deprivation, as the dominant mechanism.
  • A green-light-activated microbial protein induces apoptosis in cancer cells in preclinical models, showcasing externally controllable tumor-killing.
  • Researchers separate cognitive disengagement syndrome from ADHD, and stress-linked heart inflammation appears in women but not men, reinforcing sex-specific risk models.

r/science toggled between rewiring biology and confronting the pitfalls of perception today. The threads lean toward control—of neurons, tumors, and diagnostics—while exposing how brittle our intuitions are when the camera’s rolling or someone says “I can’t breathe.” The throughline is simple: precision is seductive, but reality always pushes back.

Rewriting the body’s circuits: from neurons to tumors to faces

The community celebrated precision interventions that alter entrenched pathways. That momentum includes findings on how psilocybin reshapes brain circuits linked to depression, weakening rigid loops and strengthening sensory-motor routes, alongside an elegant demonstration that a microbial protein triggered by green light induces apoptosis in cancer cells. It’s a confidence play: change the wiring, change the outcome.

"Now make it therapeutically available to help millions of people!" - u/fordman84 (797 points)

That engineering impulse extends to nucleic acids and development: researchers unveiled RIBOTAC molecules that hunt down a cancer-enabling RNA and quietly erase it, while developmental biologists mapped positional programs in embryonic mesenchyme that pre-mark the face, reframing how inherited features are laid down. It’s intoxicating to watch biomedicine promise specificity; the danger is we start believing alignment and translation are guaranteed.

Perception keeps sabotaging us—online, on menus, and in restraints

When science meets human attention, the gap yawns. Ethologists warn that viral pet videos often conceal stress, risk, and pain, and behavioral data show calorie labels mostly nudge only those already trying to lose weight. Policy loves signage; reality loves context. The internet rewards clicks, not care.

"I mean yeah usually the feeling of suffocation comes from too much CO2 rather than too little O2." - u/Raulr100 (2929 points)

Now apply that to life-and-death: a forensic review argues many restraint fatalities are less about oxygen scarcity than failure to expel carbon dioxide, even when someone can say “I can’t breathe.” And perception spreads within other species too; bumblebee colonies show optimism contagion via simple visual exposure. We keep trusting what we think we see; biology keeps reminding us the signal lives beneath the surface.

Precision diagnosis is overdue—and it’s not the same for everyone

Diagnostics are finally admitting nuance. Clinicians and researchers differentiate cognitive disengagement syndrome from ADHD in youth, quantifying a distinct CDS-only profile and challenging a stimulant-first reflex that treats disparate presentations as one bucket. Overlap isn’t identity; treatment should reflect that.

"Stimulants are not always very effective for it." - u/merrythoughts (274 points)

If the point is precision, cardiology must catch up: investigators report that psychosocial stress correlates with early signs of heart inflammation in women but not men. Sex-specific risk models aren’t a nice-to-have; they’re the baseline for a field that still treats “average” as universal.

Journalistic duty means questioning all popular consensus. - Alex Prescott

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