Cannabidiol pretreatment worsens THC-related psychosis in schizophrenia

The latest cross-disciplinary findings reshape computing, immunotherapy, risk models, and human behavior.

Melvin Hanna

Key Highlights

  • Adolescents who start cannabis before age 15 face roughly 4x higher odds of regular use and greater downstream health care utilization.
  • Sterilized dogs live about 1.5 years longer on average, despite intact testes exposure lowering frailty-related mortality in a Rottweiler cohort.
  • A cross-lab benchmark found Polish prompts delivered higher multi-task accuracy than English across large AI systems.

Today’s r/science slate shows how systems-thinking is reshaping what we compute, how we heal, and how we communicate risk. Across labs and lived experience, researchers and commenters are pushing on the boundaries between biology, behavior, and technology.

Engineering living systems—and language—for performance

Researchers are reframing hardware and therapy through biology: a prototyping effort to turn shiitake mushrooms into living processors that behave like memristors, while a targeted immunotherapy using nanoparticles delivering IL-12 directly to ovarian tumors promises more precise, durable immune activation. Both threads emphasize low-footprint, high-specificity design—materials that remember and immune signals that persist.

"Let me know when you can run Doom on a mushroom...." - u/spambearpig (1604 points)

Even the words we use to steer models matter: a cross-lab benchmarking study suggests Polish can be the most effective prompting language for large AI systems, outperforming English on multi-task accuracy. For scientists and educators, this is a reminder that interface choices—from a fungal memristor’s electrical vocabulary to human linguistic structure—can meaningfully shift outcomes.

Risk signals, trade-offs, and model updates

Public health research leans into complexity: a birth-cohort analysis indicates adolescents who start cannabis before 15 face markedly higher odds of regular use and downstream health care needs. Complicating prevailing beliefs, a randomized crossover trial in schizophrenia found that cannabidiol pre-treatment worsened cannabis-induced memory impairment and psychotic symptoms rather than protecting against THC.

"When I was in college I was a pretty heavy smoker, I actually stopped because I was having issues with anxiety and weed in general was just getting in the way of going out and doing stuff. I still smoke on occasion now, but its generally months or years in between. I know people don't like to hear it, but I think just like everything else, over use / abuse of weed was always going to eventually be found out to have some negative side effects...." - u/GraphicH (457 points)

Training and environment also recalibrate our risk landscape: university students who completed Stop the Bleed instruction reported increased fear of mass casualty events alongside higher self-efficacy to intervene. Meanwhile, atmospheric chemists report that wildfire smoke acts as a sunlit chemical reactor producing reactive peroxides that significantly degrade downwind urban air, signaling the need to upgrade air-quality models for a warming world.

Bodies, hormones, and identity shape behavior

Physiology and experience intertwine: qualitative interviews on exercise-induced orgasms deepen understanding of how internal sensations can integrate into sexual life across development. Comparative aging work with long-lived Rottweilers points to intact testes exposure as a buffer against frailty-related mortality, reframing how hormone dynamics may influence resilience.

"It’s important to note that this study shows that neutering raises the risk of death specifically by frailty, not by all causes. Sterilized dogs on average live 1.5 years longer than intact dogs. So get your pets sterilized." - u/hananobira (2489 points)

Culture adds another layer: surveying political psychology, researchers found that right-wing ideological dispositions correlate with stronger support for animal products and aversion to vegetarian or vegan diets. Taken together, these threads show that biology sets constraints, but social identity—and the environments we inhabit—directs which paths people take.

Every community has stories worth telling professionally. - Melvin Hanna

Related Articles

Sources

TitleUser
Shiitake mushrooms have been harnessed to function as living processors, storing and recalling data like a semiconductor chip but with almost no environmental footprint. Scientists show fungi can be trained to act like memristors microscopic components to process and store data in computer chips.
11/02/2025
u/mvea
6,016 pts
Teens who start using cannabis before 15 are 4 more likely to use it regularly by 17 and face higher risks of depression, anxiety, and physical health issues in young adulthood compared to peers who never used cannabis during adolescence.
11/02/2025
u/PhorosK
2,851 pts
Exercise-induced orgasms: Scientists are diving deep into the unusual phenomenon Through in-depth interviews, researchers found that these experiences often begin in childhood, are felt as a deep, internal sensation, and can be integrated into a persons sexual life.
11/02/2025
u/chrisdh79
2,167 pts
Dog testes offer clues to healthy aging and frailty resilience in men. Early neutering was linked to worse outcomes. Dogs neutered before age 2 had 16% increase in mortality risk for every small rise in frailty score. Those kept intact for more than about 10 years showed no increased mortality.
11/02/2025
u/mvea
1,674 pts
Researchers surveyed right-wing supporters to see if their ideologies influenced meat, dairy, egg, and fish consumption. The right-wing ideologies of Social Dominance and Authoritarianism were found to increase their support of these animal products and their aversion to vegetarianism and veganism.
11/02/2025
u/James_Fortis
1,295 pts
New nanoparticles stimulate the immune system to attack ovarian tumors: Targeted particles carrying the cytokine IL-12 can jump-start T cells, allowing them to clear tumors while avoiding side effects.
11/02/2025
u/fchung
367 pts
Contrary to expectations, a new study finds that pre-treatment with cannabidiol (CBD) worsened cannabis-induced memory impairment and psychotic symptoms in schizophrenia patients challenging the belief that CBD protects against THC.
11/02/2025
u/PhorosK
334 pts
Polish is the most effective language for prompting AI, study reveals
11/02/2025
u/christopher123454321
289 pts
Participation in Stop The Bleed training raised students fears of mass casualty events and self-efficacy
11/03/2025
u/batman613
195 pts
Wildfire smoke not only pollutes air but also acts as a hidden chemical reactor, producing harmful peroxides when exposed to sunlight and significantly worsening air quality downstream, putting urban residents at increased respiratory health risk
11/02/2025
u/nohup_me
156 pts