Quitting smoking normalizes dementia risk within a decade

The latest findings span hormone therapy, vaccines, cannabis risks, and ice XXI.

Alex Prescott

Key Highlights

  • Quitting smoking in middle age can normalize dementia risk within 10 years.
  • A Medicare-scale study shows the recombinant shingles vaccine cuts infection risk by ~50% and performs best with two doses.
  • Reducing daily sitting by 30 minutes improves metabolic flexibility in clinical measurements.

r/science spent the day toggling between “fix your brain” pragmatism and “break reality” physics, and the community leaned hard on lived experience to challenge headlines. The through-line: modest, measurable interventions compete for attention with grand discoveries, while commenters demand stricter definitions and better context.

Neurorealism without the fatalism

The subreddit’s appetite for modifiable risk was obvious in evidence that stopping smoking in middle age can normalize dementia risk within a decade, paired with cautious enthusiasm for post‑menopause HRT being linked to lower dementia incidence. That optimism was tempered by nuance: findings that men’s brains shrink faster than women’s during aging undercut simplistic explanations for sex differences in Alzheimer’s diagnoses.

"as someone who recently restarted smoking , thanks for the reminder that I need to quit again..." - u/bon-ton-roulet (3022 points)

The edges of brain risk are not purely behavioral: community attention turned to beached dolphins showing Alzheimer‑like pathology tied to polluted waters, a stark reminder that environmental exposure can scramble cognition far beyond human anecdotes. Developmental timing also mattered, whether in a trial where recordings of a mother’s voice accelerated language‑network maturation in premature infants or in a JAMA‑linked analysis associating rising social media use in preteens with dips in reading and memory. The pattern is clear: hormones, toxins, habits, and attention economy all jostle for primacy, and none look like a silver bullet.

"Well this is existentially depressing..." - u/--SharkBoy-- (363 points)

From small nudges to big lasers

On the prevention front, r/science embraced the power of modest changes: trimming just 30 minutes of sitting improved metabolic flexibility, while a Medicare‑scale look showed the recombinant shingles vaccine halves infection risk and works best with two doses. Yet complexity intruded as headlines claimed nearly 30% who try cannabis develop a disorder alongside gene associations like CADM2 and GRM3; the commentariat immediately pressed for definitions and denominators rather than moral panic.

"30%? A lot higher than the typical 10% you hear. What is their definition?..." - u/gerningur (2034 points)

Then the subreddit veered into wonder: a high‑pressure X‑ray laser experiment unveiled ice XXI at room temperature, reminding everyone that the universe is still stranger than your wellness routine. If today’s threads argue over practical thresholds, this discovery argues for new ones—pressure, phase, and possibility—reframing “what’s normal” as something we have not yet measured.

"Kurt Vonnegut is gonna flip out when he hears about this...." - u/Agheratos (713 points)

Journalistic duty means questioning all popular consensus. - Alex Prescott

Related Articles

Sources

TitleUser
People who stop smoking in middle age can reduce their cognitive decline so dramatically that within 10 years their chances of developing dementia are the same as someone who has never smoked, research has found.
10/14/2025
u/Wagamaga
19,722 pts
Nearly 30% of people who try cannabis will go on to develop a substance use disorder Researchers have identified two key genes associated with a number of physiological and psychiatric disorders which have been linked to long-term and frequent cannabis use.
10/14/2025
u/chrisdh79
6,029 pts
Beached dolphins show signs of Alzheimer's due to polluted waters: stranded dolphins showed brain damage eerily similar to that of people with Alzheimer's. Just as people with dementia sometimes wander far from home, scientists think dolphins with Alzheimer's might get confused at sea.
10/14/2025
u/mvea
4,986 pts
Women who take HRT after menopause less likely to develop dementia, study indicates
10/14/2025
u/AffectionateSwan5129
4,826 pts
Mens brains shrink faster than womens: During ageing, men experience a greater reduction in volume across more regions of the brain than women do. This means that age-related brain changes do not explain why women are more frequently diagnosed with Alzheimers disease than men are.
10/14/2025
u/mvea
3,331 pts
A strange new phase of ice has been discovered during experiments with the world's largest X-ray laser. Named ice XXI, the bizarre phase forms at room temperature, under extreme pressure.
10/15/2025
u/sciencealert
1,581 pts
A US Medicare study found the recombinant shingles vaccine cut infection risk by over 50% in older adults, including those with weak immunity. Two doses worked best.
10/14/2025
u/calliope_kekule
551 pts
Just 30 minutes of less sitting each day can improve the body's ability to utilize fats and carbohydrates for energy production. Reducing sedentary behavior can be particularly beneficial for people who are physically inactive and have an increased risk of heart diseases and type 2 diabetes.
10/14/2025
u/universityofturku
419 pts
New analysis found that both low and high increases in social media use throughout early adolescence were significantly associated with lower performance in specific aspects of cognitive function
10/14/2025
u/Wagamaga
407 pts
Playing recordings of a mothers voice to premature babies may help their brains mature faster, according to the first randomised-controlled trial of this simple intervention. This approach could ultimately improve language outcomes for babies born too early.
10/14/2025
u/New_Scientist_Mag
339 pts